Lilemong tsa morao tjena, ka ho eketseha ha mekhoa e sa pheleng ea bophelo bo botle le khatello ea sechaba e ntseng e eketseha ea basali, palo ea liketsahalo tsa polycystic ovary syndrome ( PCOS ) e se e ntse e bonahala haholoanyane.Liphuputso tse tsoang linaheng tse ling li bontšitse hore liketsahalo tsa polycystic ovary syndrome (PCOS) ho basali ba lilemong tsa ho beleha li phahame ka 6% -15%, ha Chaena, karolo e ka holimo ho 6% -10%.
Polycystic ovary syndrome ke lefu le atisang ho hlaha ho basali ba lilemong tsa ho beleha ka lebaka la mathata a endocrine.E bonahala haholo-holo ka tsoekere e sa tloaelehang le metabolism ea lipid le ho se sebetse hantle ha bana.Mekhoa ea tlhahlobo ea kliniki ke bothata ba boemo ba li-hormone ( high androgen ), e fokotsa mathata a Ovulation le liphetoho tsa ovarian polycystic, 'me basali ba bangata ba nang le PC COS ba na le likarolo tse mpe tsa metabolism, tse kang ho hanyetsa insulin, botenya, le sebete sa steatosis.
Hona joale, ho na le lithethefatsi tse fokolang bakeng sa phekolo ea PCOS .Mokhoa o tloaelehileng ke ho ntlafatsa PCOS ka ho lebisa tlhokomelo le ho thibela ho feteletseng ha androgen ka lithethefatsi tse thibelang li-androgen.Leha ho le joalo, ho boetse ho na le bopaki ba hore lithethefatsi tse khahlanong le androgen li na le chefo e matla ea sebete, kahoo tšebeliso ea tsona e lekanyelitsoe.Ka hona, ke habohlokoa haholo ho batla ntho ea tlhaho ntle le litla-morao ho nkela lithethefatsi tsa morao-rao sebaka.
phuputso ea morao tjena ea Univesithi ea New South Wales e Australia e fumane hore lefu la polycystic ovary le amana le khaello ea NAD +, 'me liphello tsa lipatlisiso li ile tsa hatisoa koranteng ea saense "Molecular Metabolism".
Sehlopha sa lipatlisiso se ile sa qala ho kenya dihydrotestosterone (DHT) ka tlas'a litoeba tsa basali pele le ka mor'a ho kena bohlankaneng ho theha mohlala oa mouse ea PC COS, 'me ka mor'a libeke tsa 8 tsa phekolo ea NMN, insulin e potlakileng le ho lemoha ho hanyetsa insulin ea HOMA, tlhahlobo ea mamello ea glucose, mafura Ka mor'a liteko tse joalo. joalo ka histomorphometry, liphetho tsa lipalo li bontša:
1. N MN e tsosolosa N AD + boemo ba mesifa ea P COS litoeba
o fumane hore boemo ba NAD + mesifa ea litoeba tsa PCOS bo fokotsehile haholo, 'me boemo ba NAD ka har'a mesifa ea litoeba tsa PCOS bo ile ba tsosolosoa ke ho fepa ha NMN .
2. NMN e ntlafatsa ho hanyetsa insulin le botenya ho litoeba tsa PCOS
Maemo a insulin a bakoang ke DHT a feta habeli ho litoeba tsa PCOS tse itimang lijo, mohlomong a bonts'a ho hanyetsa insulin.Ka ho fepa NMN, ho ile ha fumanoa hore boemo ba insulin bo itima lijo bo khutliselitsoe boemong bo haufi le ba litoeba tse tloaelehileng.Ho phaella moo, boima ba 'mele ba litoeba tsa PCOS bo eketsehile ka 20%,' me boima ba mafura bo ile ba eketseha haholo.
3. NMN e tsosolosa mokhoa o sa tloaelehang oa lipid deposition ho PCOS litoeba
E 'ngoe ea litšoaneleho tsa lefu la polycystic ovary ke boemo ba lipid ka har'a sebete le ho kenella ha sebete sa mafura.Ka mor'a ho nka NMN, ho kenngoa ha lipid ka sebete ho litoeba tsa PCOS ho ne ho batla ho felisoa, 'me li-triglycerides sebeteng li khutlela boemong ba litoeba tse tloaelehileng.
qetellong, boemo ba NAD + mesifa ea PCOS bo fokotsehile haholo, 'me boemo ba PCOS bo fokotsehile ka ho tlatsetsa NMN, e leng selelekela sa NAD +, e ka' nang ea e-ba leano la phekolo bakeng sa phekolo ea PCOS.
litšupiso:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Ho fokotseha ha mesifa ea NAD+ ka mohlala oa mouse ea hyperandrogenism PCOS: Karolo e ka bang teng ho metabolic dysregulation.Mol Metab.2022 Sep 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub pele ho khatiso.PMID: 36096453.
Nako ea poso: Nov-17-2022