Oocyte ke tšimoloho ea bophelo ba motho, ke sele e sa holang ea lehe e qetellang e hola ho ba lehe.Leha ho le joalo, boleng ba oocyte bo fokotseha ha basali ba ntse ba tsofala kapa ka lebaka la mabaka a kang botenya, 'me li-oocyte tsa boleng bo tlaase ke tsona tse bakang thari e tlaase ho basali ba batenya.Leha ho le joalo, mokhoa oa ho ntlafatsa boleng ba li-oocyte ho basali ba batenya ke phephetso ho bo-rasaense.
Haufinyane tjena, thuto e bitsoang Administration of nicotinamide mononucleotide e ntlafatsa boleng ba oocyte ba litoeba tse nonneng e phatlalalitsoe ho Cell proliferation.Boithuto bo fumane hore tlatsetso ea nicotinamide adenine dinucleotide (NAD +) selelekela.nicotinamide mononucleosideAcid (NMN) e ka ntlafatsa ho ruruha ha mae a bomme ka katleho, ea ntlafatsa boleng ba oocyte le ho khutlisetsa boima ba 'mele oa bana ho litoeba tse tšehali tse tšehali.
Bafuputsi ba ile ba khetha litoeba tse tšehali tsa libeke tse 3 le litoeba tse tona tse 11 tsa beke ho theha mohlala oa toeba ea botenya ka lijo tse nang le mafura a mangata le ho netefatsoa ke ho rekota boima ba 'mele, tlhahlobo ea tsoekere ea mali e potlakileng le tlhahlobo ea mamello ea glucose ea molomo, ho kenella lijong. 1 Bakeng sa libeke tse 2,NMNli-supplement li ile tsa kenngoa ka matsatsi a 10 a latellanang ho bona polelo ea liphatsa tsa lefutso tse amanang le nts'etsopele ea mahe a bomme le liphatsa tsa lefutso tse amanang le ho ruruha, boholo ba mafura a maqeba a ka mpeng, mofuta oa oksijene o sebetsang oa oocyte, sebopeho sa spindlechromosome, Mitochondrial Function, actin dynamics le tšenyo ea DNA, bapisoa le liphetho tsa lipalo-palo tse bonts'ang:
1. Mokhoa oa ho ja lijo tse nang le mafura a mangata-o bakiloeng ke botenya ba mouse o ile oa thehoa ka katleho
Phaello ea FGB ea sehlopha sa lijo tse nang le mafura a mangata (HFD) e ne e lula e phahame ho feta sehlopha sa lijo tse tloaelehileng (ND), ho phaella moo, liphello tsa OGTT li bontšitse hore litoeba tsa sehlopha sa lijo tse nang le mafura a mangata (HFD) li ne li sa mamelle tsoekere.
2. NMN e ka ntlafatsa ho se tloaelehe ha metabolism ho litoeba tsa HFD
Tlatsetso leNMNtlatsetso e ile ea fokotsa palo ea mafura ho litoeba sehlopheng sa lijo tse nang le mafura a mangata ( HFD ), 'me liphello li bontša hore NMN e na le phello e sireletsang ho metabolism e sa tloaelehang ho litoeba tsa lijo tse nang le mafura a mangata (HFD) sehlopha.
3. NMN e ntlafatsa boleng ba mahe a bomme ho litoeba tsa HFD
NMN e ka ntlafatsa boleng ba mae a bomme lijong tse nang le mafura a mangata (HFD) litoeba ka ho laola polelo ea liphatsa tsa lefutso tsa bohlokoa tse amanang le tsoelo-pele ea follicle ea mahe a bomme (Bmp4, Lhx8) le ho ruruha.
4. NMN e fokotsa bokooa ba karohano ea oocyte le tšenyo ea DNA ho litoeba tsa HFD
NMN e ka fokotsa maqhubu a phahameng a bokooa ba li-spindle le li-chromosomal misalignments tse bakoang ke lijo tse nang le mafura a mangata (HFD), ho fokotsa pontšo ea γH2A.X, le ho matlafatsa lijo tse nang le mafura a mangata (HFD) -e bakoang ke tšenyo ea DNA ka ho fokotsa polelo ea Bax.
5. NMN e ka ntlafatsa boleng ba li-oocyte
NMN e ka lokisa polelo e laoloang fatše ea antioxidant SOD1 sehlopheng sa lijo tse nang le mafura a mangata (HFD), ea ntlafatsa kabo ea mitochondria, 'me e ka ntlafatsa boleng ba li-oocyte ka ho boloka botšepehi ba cytoskeleton.
6. NMN e ka tsosolosa kabo ea marotholi a lipid ho litoeba tsa HFD
Lijo tse nang le mafura a mangata (HFD) li-oocyte tsa sehlopha li ne li phahame hanyenyane ho feta lijong tse tloaelehileng (ND) li-oocyte tsa sehlopha, 'me NMN supplementation e ka fokotsa matla a fluorescence a marotholi a lipid.
7. NMN e tsosolosa boima ba 'mele ho bana ba litoeba tsa HFD
boima ba tsoalo ea bana ba sehlopha sa lijo tse nang le mafura a mangata (HFD) bo ne bo le tlase haholo ho feta sehlopha sa lijo tse tloaelehileng (ND), 'me tlatsetso ka NMN supplementation e ile ea tsosolosa boima ba tsoalo ea bana ba sehlopha sa HFD.
Phuputsong ena, bafuputsi ba bontšitse ka liteko tsa mouse hore NMN e na le bokhoni ba ho ntlafatsa boleng ba li-oocyte ho litoeba tse tšehali tse tšehali tse susumetsoang ke lijo tse mafura a mangata, 'me ba senola hore NMN e ka tsosolosa ts'ebetso ea mitochondrial le ho fokotsa ho bokella ROS ho li-oocyte tsa basali tse nonneng., Tšenyo ea DNA le mekhoa ea motheo ea kabo ea marotholi a lipid.Ka hona, thuto ena e tla fana ka leano la kalafo le ka bang teng bakeng sa ho ntlafatsa mathata a pelehi a bakoang ke botenya ho basali.
litšupiso:
1.Wang L, Chen Y, Wei J, et al.Tsamaiso ea nicotinamide mononucleotide e ntlafatsa boleng ba oocyte ba litoeba tse nonneng.Cell Prolif.2022;e13303.doi10.1111cpr.13303
Nako ea poso: Sep-28-2022