Hypopigmentation ke lefu la letlalo, le bonahatsoang haholo-holo ke phokotso ea melanin. Matšoao a tloaelehileng a kenyelletsa vitiligo, albinism le hypopigmentation kamora ho ruruha ha letlalo. Hona joale, kalafo e ka sehloohong ea hypopigmentation ke meriana ea molomo, empa meriana ea molomo e tla baka ho fokola ha letlalo, ho se phutholohe ha mala le litla-morao tse ling tse mpe. Ka hona, ho hlokahala ho hlahisa ntho ea tlhaho e se nang litla-morao ho phekola hypopigmentation.
Haufinyane tjena, Scientific Reports e phatlalalitse sengoloa se nang le sehlooho se reng "Phuputso e hlophisitsoeng e senola bokhoni ba spermidine bakeng sa kalafo ea hypopigmentation |ka ho tsitsisa liprotheine tse amanang le melanogenesis". Liphetho li bontša hore spermidine e ka phekoloa ka ho tsitsisa liprotheine tse amanang le melanogenesis. hypopigmentation.
Kalafo ea Spermidine e eketsa tlhahiso ea melanin
E le ho ithuta phello ea spermidine tlhahisong ea melanin, sehlopha sa lipatlisiso se ile sa phekola melanin liseleng tsa MNT-1 ka maemo a fapaneng a spermidine. Ka tlhahlobo ea bongata, ho fumanoe hore kalafo ea spermidine e ekelitse tlhahiso ea melanin.
Spermidine e ka laola tsamaiso ea ho senyeha ha protheine e amanang le melanogenesis
E le ho paka hore spermidine e ka laola liphatsa tsa lefutso tse amehang ho senyeheng ha protheine, sehlopha sa lipatlisiso se fumane liphatsa tsa lefutso tse 181 li theohile 'me liphatsa tsa lefutso tse 82 li theohile li laoloa ka ho lemoha lisele tse phekoloang spermidine ka mokhoa o hlophisehileng, ho sa kenyeletsoe liphatsa tsa lefutso tse amanang le melanogenesis. Ho paka ka ho eketsehileng, sehlopha sa lipatlisiso se hlahlobile phello ea spermidine boemong ba tlhahiso ea lelapa la liphatsa tsa lefutso la tyrosinase TYR, TRP-1 le TRP-2, e leng liphatsa tsa lefutso tse laolang tlhahiso ea melanin haufi-ufi. Boemo ba tlhahiso ea mRNA bo tiisitse hore spermidine ha ea fetola tlhahiso ea liphatsa tsa lefutso tse amanang le melanogenesis. Leha ho le joalo, ts'ebetso ea liphatsa tsa lefutso tse 'maloa e fetoloa ke spermidine' me e amana le ho senyeha ha protheine. Liphatsa tsa lefutso tse 'maloa tse fetotsoeng li amana le ubiquity, e leng sistimi ea ho senyeha ha protheine e amanang le melanogenesis.
三．Spermidine e laola botsitso ba liprotheine mme e khothalletsa tlhahiso ea melanin.
Tlhahiso ea melanin e laoloa ke ho leka-lekana ha ho etsoa le ho senyeha ha liprotheine tse amanang le melanin. Spermidine e phekola liphatsa tsa lefutso tsa TYR, TRP-1 le TRP-2. Ka ketso ea liphatsa tsa lefutso tsa transporter SLC3A2, SLC7A1, SLC18B1 le SLC22A18, e ka eketsa boemo ba li-polyamine liseleng, ka hona e eketsa botsitso ba liprotheine tse amanang le tlhahiso ea melanin ho khothaletsa tlhahiso ea melanin ka har'a 'mele.
Qetellong, phuputso ena e bonts'a hore motsoako oa tlhaho oa spermidine o na le karolo e ka bang teng kalafong ea hypopigmentation, 'me o na le bohlokoa bo itseng ba ts'ebeliso lefapheng la litlolo le lihlahisoa tsa bophelo bo botle nakong e tlang.
Referense:
[1].Brito, S., Heo, H., Cha, B. jj. Phuputso e hlophisitsoeng e senola bokgoni ba spermidine bakeng sa kalafo ya hypopigmentation ka ho tsitsisa diprotheine tse amanang le melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Nako ea poso: Loetse-28-2022