Hypopigmentation ke lefu la letlalo, haholo-holo le bonahatsoang ke ho fokotseha ha melanin.Matšoao a tloaelehileng a kenyelletsa vitiligo, albinism le hypopigmentation ka mor'a ho ruruha ha letlalo.Hona joale, phekolo e ka sehloohong ea hypopigmentation ke meriana ea molomo, empa meriana ea molomo e tla baka atrophy ea letlalo, ho se utloise bohloko ha mala le litla-morao tse ling tse mpe.Ka hona, hoa hlokahala ho hlahisa ntho ea tlhaho ntle le litla-morao ho phekola hypopigmentation.
Haufinyane tjena, Scientific Reports e hatisitse sehlooho se reng "Ho hlahlojoa ka mokhoa o hlophisitsoeng ho senola bokhoni ba spermidine bakeng sa phekolo ea hypopigmentation | ka ho tsitsisa ha liprotheine tse amanang le melanogenesis".Liphello li bontša hore spermidine e ka phekoloa ka ho tsitsisa liprotheine tse amanang le melanogenesis.hypopigmentation.
Kalafo ea spermidine e eketsa tlhahiso ea melanin
E le ho ithuta phello ea spermidine tlhahiso ea melanin, sehlopha sa lipatlisiso se ile sa tšoara melanin ka liseleng tsa MNT-1 tse nang le mefuta e sa tšoaneng ea spermidine.Ka tlhahlobo ea bongata, ho ile ha fumanoa hore phekolo ea spermidine e ekelitse tlhahiso ea melanin.
Spermidine e ka laola tsamaiso ea ho senyeha ha protheine e amanang le melanogenesis
E le ho paka hore spermidine e ka laola liphatsa tsa lefutso tse amehang ho senyeha ha protheine, sehlopha sa lipatlisiso se fumane liphatsa tsa lefutso tse 181 tse laoloang fatše le liphatsa tsa lefutso tsa 82 tse laoloang ke ho lemoha ka mokhoa o hlophisitsoeng lisele tse tšoaroang ke spermidine, ntle le liphatsa tsa lefutso tse amanang le melanogenesis.Ho paka ka ho eketsehileng, sehlopha sa lipatlisiso se ile sa hlahloba phello ea spermidine boemong ba polelo ea tyrosinase gene family TYR, TRP-1 le TRP-2, e leng liphatsa tsa lefutso tse laolang tlhahiso ea melanin haufi-ufi.Boemo ba polelo ea mRNA bo netefalitse hore spermidine ha ea ka ea fetola polelo ea liphatsa tsa lefutso tse amanang le melanogenesis.Leha ho le joalo, ts'ebetso ea liphatsa tsa lefutso tse 'maloa e fetoloa ke spermidine mme e amana le ho senyeha ha protheine.Liphatsa tsa lefutso tse 'maloa tse fetotsoeng li amana le ho ba hohle, e leng mokhoa oa ho senyeha ha protheine o amanang le melanogenesis.
三．Spermidine e laola botsitso ba liprotheine mme e khothaletsa tlhahiso ea melanin.
Tlhahiso ea melanin e laoloa ke ho leka-lekana ha motsoako le ho senyeha ha liprotheine tse amanang le melanin.Spermidine e tšoara liphatsa tsa lefutso tsa TYR, TRP-1 le TRP-2.Ka ketso ea liphatsa tsa lefutso tsa transporter SLC3A2, SLC7A1, SLC18B1 le SLC22A18, e ka eketsa boemo ba polyamine liseleng, kahoo e eketsa botsitso ba liprotheine tse amanang le tlhahiso ea melanin ho khothalletsa tlhahiso ea melanin ka vivo.
Qetellong, thuto ena e bontša hore motsoako oa tlhaho oa spermidine o na le karolo e ka 'nang ea e-ba teng ho phekola hypopigmentation,' me o na le boleng bo itseng ba kopo lefapheng la litlolo le lihlahisoa tsa bophelo bo botle nakong e tlang.
Referense:
[1].Brito, S., Heo, H., Cha, B. et al.Ho hlahlojoa ka mokhoa o hlophisitsoeng ho senola bokhoni ba spermidine bakeng sa phekolo ea hypopigmentation ka ho tsitsa ha liprotheine tse amanang le melanogenesis.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Nako ea poso: Sep-28-2022