Clenbuterol, ke β2-adrenergic agonist (β2-adrenergic agonist), e tšoanang le ephedrine (Ephedrine), e atisa ho sebelisoa ka meriana ho phekola lefu le sa foleng la matšoafo (COPD), E boetse e sebelisoa e le bronchodilator ho imolla ho mpefala ha asthma.Mathoasong a lilemo tsa bo-1980, k'hamphani ea Amerika ea Cyanamid e ile ea fumana ka phoso hore e na le liphello tse hlakileng tsa ho khothalletsa khōlo, ho ntlafatsa sekhahla sa nama le ho fokotsa mafura, kahoo e ne e sebelisoa e le clenbuterol ho rua liphoofolo.Leha ho le joalo, ka lebaka la litla-morao tsa eona, European Community e ile ea thibela tšebeliso ea clenbuterol e le tlatsetso ea lijo ho tloha ka January 1, 1988. E thibetsoe ke FDA ka 1991. Ka 1997, Lekala la Temo la Rephabliki ea Batho ba Chaena le thibetse ka tieo. tšebeliso ea li-hormone tsa beta-adrenergic tlhahisong ea lijo le leruo la liphoofolo, 'me Clenbuterol hydrochloride e behiloe pele.
Leha ho le joalo, Clenbuterol ea morabe e sa tsoa bontšoa ho fokotsa kotsi ea lefu la Parkinson.Ho netefatsa hore na (kapa ka bobeli) li-isomers li hlahisa phello ena, Clenbuterol enantiomer e hloekileng e hloka ho ithutoa ka thoko.
Sehloohong sa morao tjena, sehlopha sa lipatlisiso sa Elisabeth Egholm Jacobsen oa Lefapha la K'hemistri, Univesithi ea Norwegian ea Saense le Theknoloji, ka ts'ebelisano le Dr. Zhu Wei oa Shangke Bio, o ile a etsa hore ho be le motsoako oa ketoreductase KRED le cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R) -1-(4-Amino-3,5-dichlorophenyl) -2-bromoethhan-1-ol, ee> 93%;le (S)-N-(2 e entsoe ka mokhoa o tšoanang ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee>98%.Likarolo tse peli tse ka holimo ke li-precursors tsa clenbuterol isomers.Ketoreductase ES-KRED-228 e sebelisitsoeng thutong ena e ne e tsoa ho Shangke Biopharmaceutical (Shanghai) Co., Ltd. Sephetho sa lipatlisiso "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" e ile ea hatisoa ka "Catalysts" ka. La 4 Pulungoana 2018.
Nako ea poso: Aug-26-2022