β-Nicotinamide adenine dinucleotide (asiti e sa lefelloeng) (NAD)
NAD ke coenzyme e tloaelehileng haholo ea dehydrogenase linthong tse phelang.E kenya letsoho liketsong tsa redox linthong tse phelang, 'me e tsamaisa le ho fetisetsa lielektrone bakeng sa lintho tse arabelang.Dehydrogenase e bapala karolo ea bohlokoa ho metabolism ea motho.Metsamao e meng ea mantlha ea metabolism ea 'mele oa motho, joalo ka ho bola ha protheine, ho bola ha lik'habohaedreite, le ho bola ha mafura, e ke ke ea etsoa ka mokhoa o tloaelehileng ntle le dehydrogenase, mme batho ba tla lahleheloa ke matšoao a bohlokoa.Mme hobane motsoako oa NAD le dehydrogenase o ka khothaletsa metabolism, kahoo NAD ke karolo ea bohlokoa ea 'mele oa motho.Ho latela ts'ebeliso ea sehlahisoa, e ka aroloa ka limaraka tse latelang: mophato oa biotransformation, boemo ba reagent ea tlhahlobo, boemo ba lijo tsa bophelo bo botle, API le lisebelisoa tse tala tsa ho lokisa.
| Lebitso la Lik'hemik'hale | Nicotinamide adenine dinucleotide (asiti e sa lefelloeng) |
| Litlhaloso tse tšoanang | β-Nicotinamide adenine dinucleotide |
| Nomoro ea CAS | 53-84-9 |
| Boima ba Molek'hule | 663.43 |
| Foromo ea limolek'hule | C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Sebaka se qhibilihang | 140-142 °C (ho senyeha) |
| mocheso oa polokelo. | -20°C |
| ho qhibiliha | H2O: 50 mg/mL |
| sebopeho | Phofo |
| mmala | Bosoeu |
| Merck | 14,6344 |
| BRN | 3584133 |
| Botsitso: | E tsitsitseng.Hygroscopic.Ha e lumellane le lisebelisoa tse matla tsa oxidizing. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Ntho ea Teko | Litlhaloso |
| Ponahalo | Phofo ea kristale e tšoeu ho isa bosoeu |
| Tlhahlobo ea mahlaseli a UV εho 260 nm le pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Solubility | 25mg/mL 25mg/mL ka metsing |
| Likahare (ka tlhahlobo ea enzymatic le ADH ho pH 10, ho sebelisoa spectrophotometer, abs.340nm, ka lebaka la anhydrous) | ≥98.0% |
| Assay (ka HPLC, motheong oa anhydrous) | 98.0~102.0% |
| Bohloeki (ka HPLC,% sebaka) | ≥99.0% |
| Likahare tsa metsi (ka KF) | ≤3% |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka thata lefifing, ho boloka nako e telele ho 2 ~ 8 ℃.
Biotransformation grade: E ka sebelisoa bakeng sa motsoako oa biocatalytic oa li-intermediate tsa meriana le li-API, haholo-holo ka li-enzyme tse thusang, tse kang ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase ( GDH), joalo-joalo, e ka sebelisanang ho fetolela li-intermediate tse fapaneng tsa amino acid le lithethefatsi tse ling tse amanang le tsona.Hajoale, lifeme tse ngata tsa lapeng tsa meriana li se li qalile ho sebelisa phetolo ea enzyme ea tlhaho, mme tlhoko ea mmaraka ea NAD + e ntse e hola ka potlako.
Mophato oa reagent ea ho hlahloba: E kopantsoe le mefuta e fapaneng ea li-enzyme tsa tlhahlobo, joalo ka lisebelisoa tse tala tsa lisebelisoa tsa tlhahlobo.
Boemo ba lijo tsa bophelo bo botle: NAD ke coenzyme ea dehydrogenase.E na le karolo e ke keng ea nkeloa sebaka ho glycolysis, gluconeogenesis, tricarboxylic acid cycle, le ketane ea ho hema, e bapala karolo ea bohlokoa tlhahisong ea matla, 'me e thusa tlhahisong ea L-dopa, e fetohang dopamine Neurotransmitters.Haholo-holo lilemong tsa morao tjena, ho fumanoe hore ke "enjene" le "fuel" ts'ebetsong ea ho lokisa tšenyo ea lisele.Ho ea ka lipatlisiso, tlatsetso ea li-coenzymes (ho kenyeletsoa NMN, NR, NAD, NADH) in vitro e ka ntlafatsa matla a antioxidant a lisele tsa lisele, ho thibela pontšo ea apoptosis, ho khutlisetsa tšebetso e tloaelehileng ea lisele, ho thibela ho hlaha ha mafu kapa ho thibela tsoelo-pele ea mafu.
Ho phaella moo, li-coenzymes li ka ntlafatsa bokhoni ba ho arabela ha 'mele oa ho itšireletsa mafung ka ho kenya ts'ebetsong le ho khothalletsa ho hōla ha lisele tsa tlhaho tsa ho itšireletsa mafung, ho hlahisa lintho tse khahlanong le ho ruruha le ho hatella lisele tsa T tse laolang.Nicotinamide dinucleotide oxidation state (NAD +) ke coenzyme e fumanoang liseleng tsohle tse phelang.E bapala karolo ea bohlokoa lits'ebetsong tse makholo tsa metabolic liseleng, e nka karolo liketeng tsa karabelo ea 'mele, hape ke setho sa bohlokoahali sa ketane ea lipalangoang tsa elektronike.Mofani oa haerojene;ka nako e ts'oanang, coenzyme I e sebetsa e le eona feela substrate ea li-enzyme tse amanang le 'mele, e thusang ho boloka tšebetso ea li-enzyme.
Nicotinamide mononucleotide (NMN) ke motsoako oa pele oa nicotinamide adenine dinucleotide oxidation state (NAD+), e amehang ho kopanngoeng ha NAD ka vivo.Ka 2013, Moprofesa David Sinclair oa Sekolo sa Bongaka sa Harvard o fumane hore ka lilemo, boemo ba cofactor coenzyme I (NAD +) ea protheine ea nako e telele 'meleng e ntse e fokotseha, e leng se lebisang ho fokotseha ha mosebetsi oa mitochondrial oa "dynamo" ea sele, e bakang botsofali. , le mabaka a sa tšoaneng ’meleng.Ho se sebetse hantle ha mofuta ona oa ts'ebetso ho hlahisoa.Ho ea ka letoto la lithuto tsa hae, litaba tsa NAD + 'meleng oa motho li fokotseha ka lilemo, e leng se bakang botsofali bo potlakileng ho tloha lilemong tsa 30, ka makhopho, ho phomola ha mesifa, ho bokella mafura le mafu a kang lefu la pelo, khatello e phahameng ea mali, stroke. , lefu la tsoekere le lefu la Alzheimer li ile tsa eketsa kotsi.Senotlolo sa bophelo bo bolelele ke ho eketsa boemo ba coenzyme I (NAD+) 'meleng, ho eketsa sekhahla sa metabolism ea lisele, le ho susumetsa matla a bocha a ka bang teng.
API le lisebelisoa tsa ho lokisa: NAD + e sebelisoa liente bakeng sa kalafo / taolo ea bokhoba ba lithethefatsi, ho kenyeletsoa kalafo ea methapo ea NAD IV e kentsoeng United States, Europe, Russia, Afrika Boroa, Mexico, Amerika Boroa, Asia Boroa-bochabela le linaheng tse ling.Lihlahisoa tse itokiselitseng li-pharmacy, tse tšoanang le li-pharmacy tsa Amerika, li ka reka thepa e tala bakeng sa ho fana ka tsona, joalo ka litokisetso tsa sepetlele sa Chaena, e laola boleng ba thepa e tala ka boeona, 'me e lokisa litokisetso tsa meriana.
