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Phosphorylse ea Nucloside (NP)
Mabapi le phosphorylse ea nucleoside
Ho na le mefuta e 3 ea lihlahisoa tsa enzyme ea NP (Palo e le ES-NP-101~ ES-NP-103) e ntlafalitsoeng ke SyncoZymes. ES-NP-101 ke purine nucleoside phosphorylase, ES-NP-102 le ES-NP-103 ke pyrimidine nucleoside phosphorylase. Nucleosidephosphorylase e ka qhala li-nucleosides hore e be metheo le pentose phosphate. Nucleoside phosphorylase e ka aroloa ka purine nucleoside phosphorylase le pyrimidine nucleoside phosphorylase ho latela khetho ea metheo ea nucleoside. Purine nucleoside phosphorylase e ka fetola adenosine ho adenine, inosine ho hypoxanthine, guanosine ho guanine, 'me ea hlahisa ribose phosphate ka nako e le' ngoe. Pyrimidine nucleoside phosphorylase e ka fetola uridine ho uracil 'me ea hlahisa ribose phosphate.
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Hydroaminase (HAM)
Mabapi le Hydroaminase
Ho na le mefuta e 'meli ea sehlahisoa sa enzyme ea HAM (Nomoro e le ES-HAM-101~ ES-HAM-102) e ntlafalitsoeng ke SyncoZymes. HAM e ka susumetsa ammoniation ea enoic acid kapa li-derivatives tsa eona ho hlahisa chiral amino acid. HAM e ka sebelisoa ho kopanya chiral amino acid (kapa chiral amines) ho tsoa ho enoic acid (kapa alkenes). Mofani oa ammonia, joalo ka metsi a ammonia kapa letsoai la ammonium, oa hlokahala.
Mofuta oa karabelo ea catalytic ea Hydroaminase
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CALB e sa sisinyeheng
CALB
Lipase B e kopantsoeng hape e tswang ho Candida antarctica (CALB) e hlahiswa ka ho belisoa ka metsing ka Pichia pastoris e fetotsweng ka dijini.
CALB e ka sebelisoa mohatong oa metsi kapa mohato oa tlhaho oa ho etsa li-catalytic esterification, esterolysis, transesterification, synthesis ea polyester e bulang selikalikoe, aminolysis, hydrolysis ea amides, acylation ea amines le karabelo ea ho eketsa.
CALB e na le khetho e phahameng ea chiral le khetho ea maemo, kahoo e ka sebelisoa haholo indastering ea ho sebetsana le oli, lijo, meriana, litlolo le lik'hemik'hale tse ling.
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Imeile:lchen@syncozymes.com
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NADH oxidase (NOX)
Mabapi le NADH oxidase
ES-NOX (NADH oxidase): NOX e susumetsa ho kenngwa ha NADH ho NAD+, mme ke ya oxidoreductase. Mokgweng wa ho kenngwa ha oxidation, O2 e a hlokahala e le oxidative, mme e fokotswa ho H2O kapa H2O2. Ho na le mefuta e 4 ya dihlahiswa tsa enzyme ya NOX (ES-NOX-101~ES-NOX-104) tse ntshetsweng pele ke khamphani ya rona, tse ka sebediswang bakeng sa ho ntjhafatsa oxidation ya coenzyme NAD+.
Mofuta oa karabelo ea catalytic:
or
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Imeile:lchen@syncozymes.com
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Phenylalanine ammonia lyase (PAL)
Mabapi le Phenylalanine ammonia lyase
ES-PAL: Sehlopha sa dienzyme tse susumetsang ho ntsha L-phenylalanine ka kotloloho ho transcinnamic acid. Syncozymes e hlahisitse dintho tse 10 tsa phenylalanine ammonia lyase (e ngotsweng ka nomoro ya ES-PAL-101~ES-PAL-110), tse ka sebediswang ho ntsha kapa ho arabela ka morao ho phenylalanine le di-derivatives tsa yona.
Mofuta oa karabelo ea catalytic:
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Catalase (CAT)
Mabapi le Catalase
ES-CAT (Catalase): e susumetsa ho bola ha H2O2 hore e be oksijene le metsi. E fumaneha haholo-holo ho mitochondria, endoplasmic reticulum, sebete sa phoofolo le lisele tse khubelu tsa mali, haholo-holo sebeteng se nang le khatello e phahameng, e fanang ka ts'ireletso ea antioxidant bakeng sa 'mele. Ho biocatalysis, e sebelisoa haholo ho tlosa hydrogen peroxide ea sehlahisoa se latelang le ho fokotsa thibelo le ho se sebetse ha enzyme ke hydrogen peroxide. Ho na le mofuta o le mong feela oa lihlahisoa tsa enzyme tsa CAT tse ntlafalitsoeng ke SyncoZymes (Nomoro e le ES-CAT).
Mofuta oa karabelo ea catalytic:
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Lysine oxidase (LO)
Mabapi le Lysine oxidase
ES-LO (Lysine oxidase): e susumetsa oxidation ea L-lysine ho 6-amino-2-oxohexanoic acid (kapa lactone ea eona). Ho na le mofuta o le mong feela oa sehlahisoa sa enzyme ea LO (Nomoro e le ES-LO) e ntlafalitsoeng ke SyncoZymes.
Mofuta oa karabelo ea catalytic:
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Phosphokinase (PKase)
Mabapi le Phosphokinase
ES-PKase (Phosphokinase): e susumetsa phetiso ea lihlopha tsa phosphate ho ATP ho ea metsoakong e meng. E boetse e susumetsa phetiso ea lihlopha tsa phosphate ho li-nucleoside tse ling tsa triphosphate ka linako tse ling. Bongata ba kinase bo hloka li-ion tsa tšepe tse divalent ho kenya letsoho karabelong (ka kakaretso Mg2+). Ho na le mefuta e 21 ea lihlahisoa tsa enzyme ea PKase (Nomoro e le ES-PKase101~ ES-PKase-121) e ntlafalitsoeng ke SyncoZymes.
Mofuta oa karabelo ea catalytic:
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Cyclooxygenase (COX)
Mabapi le Cyclooxygenase
ES-COX (Cyclooxygenase): e susumetsa phetoho ea likhokahano tsa C=C ho epoxide. Ho na le mefuta e 11 ea lihlahisoa tsa enzyme ea COX (Palo e le ES-COX101~ ES-COX-111) e ntlafalitsoeng ke SyncoZymes. Ho latela mokhoa o fapaneng oa ho etsa li-catalytic, COX ea SyncoZymes e arotsoe ka haloperoxidase le styrene monooxygenase. ES-COX101, 102, 107-111 ke ea haloperoxidase, ha ES-COX103-106 e le ea styrene monooxygenase.
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Cyclohexanone monooxygenase (CHMO)
Mabapi le Cyclohexanone monooxygenase
ES-CHMO (Cyclohexanone monooxygenase): Baeyer Villiger monooxygenase (BVMO) e nang le cyclohexanone e le substrate, e ka kopanya cyclohexanone le cyclohexanol ka oksijene.
Ke mofuta oa enzyme e itšetlehileng ka flavin. Flavin e nang le oxidized e fokotsoa ho ba flavin nakong ea potoloho ea ho fokotsa coenzyme II (NADPH) bakeng sa oxidation e latelang. Ka hona, cofactor NADPH ea hlokahala potolohong ea flavin. Ho na le mofuta o le mong feela oa sehlahisoa sa enzyme ea CHMO (Nomoro e le ES-CHMO101) e ntlafalitsoeng ke SyncoZymes, e ka sebelisoang ho oxidation cyclohexanone ho ba cyclohexanone.
Mofuta oa karabelo ea catalytic:
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Imeile:lchen@syncozymes.com
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Carboxylic acid reductase (CAR)
Mabapi le Carboxylic acid reductase
ES-CAR (Carboxylic acid reductase): e thusa ho fokotsa sehlopha sa carboxyl ho ba sehlopha sa aldehyde. Ts'ebetsong ea catalytic, ho kenya tšebetsong ha ATP le coenzyme NADPH lia hlokahala e le li-transporter tsa haeterojene. Ho na le mefuta e 'meli ea lihlahisoa tsa enzyme ea CAR (Nomoro e le ES-CAR101~ ES-CAR-102) e ntlafalitsoeng ke SyncoZymes.
Mofuta oa karabelo ea catalytic:
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Imeile:lchen@syncozymes.com
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Phenylalanine dehydrogenase (PDH)
Mabapi le Phenylalanine dehydrogenase
ES-PDH: Sehlopha sa oxidoreductase. Karabelo e ntle e ka susumetsa ho tlosoa ha oxidative ha letsoai la phenylalanine la L ha le le teng ho NAD ho hlahisa letsoai la phenylpyruvate, 'me karabelo e fapaneng e ka susumetsa tlhahiso ea letsoai la amino acid le tsamaellanang le letsoai la phenylpyruvate. Syncozymes e hlahisitse lintho tse 8 tsa phenylalanine dehydrogenase (tse nkiloeng ka nomoro ea ES-PDH-101~ES-PDH-108). ES-PDH e ka sebelisoa ho lokisa letsoai la phenylalanine kapa letsoai la amino acid le tsamaellanang le letsoai la phenylpyruvic acid kapa li-derivatives.
Mofuta oa karabelo ea catalytic:
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Imeile:lchen@syncozymes.com
