Imine reductase (IRED)
Tlhaloso e Khutšoanyane:
Mabapi le Imine reductase
ES-IRED: Sehlopha sa li-enzyme tse etsang hore ho be le phokotso ea C=N bond ho CN bond.Ke ea enzyme ea redox, e nang le coenzyme NADPH bakeng sa lipalangoang tsa haedrojene.Ho ea ka khetho ea chiral ea lihlahisoa, li ka aroloa ka R-IRED le S-IRED.Li-syncozymes li hlahisitse 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), e ka sebelisoang haholo phokotsong ea regioselective le stereoselective ea imines ho lokisa chiral amines.
Mofuta oa karabelo ea Catalytic:
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E-mail:lchen@syncozymes.com
| Li-enzyme | Khoutu ea Sehlahisoa | Tlhaloso |
| Phofo ea enzyme | ES-IRED-101~ ES-IRED-114 | sehlopha sa 14 Imine Reductase, 50 mg ka 'ngoe |
| 96-Hantle-Enzyme Screening Kit | ES-IRED-1400 | sehlopha sa 14 Imine Reductase, 1 mg ka 'ngoe |
★ Boemo bo phahameng ba substrate.
★ Khetho e matla ea chiral.
★ Phetoho e phahameng.
★ Lihlahisoa tse fokolang.
★ Maemo a bonolo a karabelo.
★ Ho baballa tikoloho.
➢ Ka tloaelo, sistimi ea karabelo e tlameha ho kenyelletsa substrate, tharollo ea buffer, enzyme, coenzyme, le coenzyme regeneration system.
➢ Mefuta eohle ea li-ES-IRED tse tsamaellanang le maemo a fapaneng a karabelo e nepahetseng li lokela ho ithutoa ka bonngoe.
➢ High concentration Substrate kapa sehlahisoa se nang le sona se ka sitisa tšebetso ea ES-IRED.Leha ho le joalo, inhibition e ka imoloha ka ho eketsoa ha sehlopha sa substrate.
Mohlala 1(Biosynthesis of chiral 2-methyl pyrrolidine)(1):
Mohlala 2(Biosynthesis ea amine ea bobeli)(2):
Mohlala 3 (Phokotso ea Imines ea Libaesekele)(3):
Boloka lilemo tse 2 ka tlase ho -20 ℃.
Le ka mohla u se ke ua kopana le maemo a feteletseng a kang: mocheso o phahameng, pH e phahameng / tlase le solvent e phahameng ea organic.
1. Scheller PN, Fademrecht S, Hofelzer S, et al.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, le ba bang.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al.Adv.Synth.Catal.2015, 357, 1692-1696.
