Imine reductase (IRED)
Tlhaloso e Khutšoanyane:
Mabapi le Imine reductase
ES-IRED: Sehlopha sa dienzyme tse susumetsang phokotso ya tlamo ya C=N ho tlamo ya CN. Ke ya enzyme ya redox, e nang le coenzyme NADPH bakeng sa ho tsamaisa haeterojene. Ho ya ka kgetho ya chiral ya dihlahiswa, di ka arolwa ka R-IRED le S-IRED. Di-Syncozymes di thehile di-imine reductase tse 15 (numbIRED ES-IRED-101-ES-IRED-115), tse ka sebediswang haholo phokotsong ya regioselective le stereoselective ya imines ho lokisa di-chiral amine.
Mofuta oa karabelo ea catalytic:
Selefouno/Wechat/WhatsApp: +86-13681683526
Imeile:lchen@syncozymes.com
| Li-enzyme | Khoutu ea Sehlahisoa | Tlhaloso |
| Phofo ea Enzyme | ES-IRED-101~ ES-IRED-114 | sete ea 14 Imine Reductase, 50 mg ka 'ngoe |
| Sete ea ho Hlahloba Li-enzyme tsa 96-Well | ES-IRED-1400 | sete ea 14 Imine Reductase, 1 mg ka 'ngoe |
★ Ho ikhetha ha substrate haholo.
★ Khetho e matla ea chiral.
★ Phetoho e phahameng.
★ Lihlahisoa tse fokolang tse setseng.
★ Maemo a bobebe a karabelo.
★ E sireletsa tikoloho.
➢ Ka tlwaelo, sistimi ya karabelo e lokela ho kenyeletsa substrate, tharollo ya buffer, enzyme, coenzyme, le sistimi ya tsosoloso ya coenzyme.
➢ Mefuta eohle ea li-ES-IRED tse tsamaellanang le maemo a fapaneng a karabelo a nepahetseng e lokela ho ithutoa ka bonngoe.
➢ Karoloana e phahameng ea lintho tse ka sebelisoang e ka sitisa ts'ebetso ea ES-IRED. Leha ho le joalo, thibelo e ka fokotsoa ka ho eketsoa ha karoloana e ka sebelisoang.
Mohlala oa 1 (Biosynthesis ea chiral 2-methyl pyrrolidine)(1):
Mohlala oa 2 (Biosynthesis ea amine ea bobeli)(2):
Mohlala oa 3 (Phokotso ea Limine tsa Cyclic)(3):
Boloka lilemo tse 2 ka tlase ho -20℃.
Le ka mohla u se ke ua kopana le maemo a feteletseng a kang: mocheso o phahameng, pH e phahameng/e tlase le motsoako o nang le manyolo o nang le mahloriso a mangata.
1. Scheller PN, Fademrecht S, Hofelzer S, et al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, jj. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al. Adv. Synth. Catal. 2015, 357, 1692-1696.
