Oxynitrilases (HNL)

Tlhaloso e Khutšoanyane:

Mabapi le li-oxynitrilases

ES-HNLs: Enzyme ea sehlopha e etsang hore enantioselectively e tlatse ho eketsoa ha HCN ho aldehydes (ketones) ho fumana R kapa S type cyanide alcohols, e ka fetoloang habonolo mefuteng e mengata ea lithethefatsi kapa li-intermediate tsa lithethefatsi ka mokhoa oa lik'hemik'hale.
Ho na le mefuta e 29 ea lihlahisoa tsa oxynitrilase (Palo e le ES-HNL-101～ES-HNL-129) e ntlafalitsoeng ke SyncoZymes.SZ-HNL ke sesebelisoa se molemo ho regio- le stereo- selective synthesis ea (R) -cyanohydrins kapa (S) -cyanohydrins ho tloha mefuta e fapaneng ea monko o monate, aliphatic le heterocyclic aldehydes kapa esita le ketone.
Mofuta oa karabelo ea Catalytic:

Oxynitrilases HNL2

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E-mail:lchen@syncozymes.com

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Lintlha tsa Sehlahisoa:

Li-enzyme	Khoutu ea Sehlahisoa	Tlhaloso
Phofo ea enzyme	ES-HNL-101~ ES-HNL-129	sehlopha sa 29 oxynitrilases, 50 mg e 'ngoe le e 'ngoe lintho tse 29 * 50mg / ntho, kapa bongata bo bong
Skrine Kit (SynKit)	ES-HNL-1800	sehlopha sa 18 (S) -oxynitrilases, 1 mg ka 'ngoe lintho tse 18 * 1mg / ntho
Skrine Kit (SynKit)	ES-HNL-1100	sehlopha sa 11 (R) -oxynitrilases, 1 mg ka 'ngoe 11items * 1mg / ntho

Melemo:

★ Boemo bo phahameng ba substrate.
★ Khetho e matla ea chiral.
★ Phetoho e phahameng.
★ Lihlahisoa tse fokolang.
★ Maemo a bonolo a karabelo.
★ Ho baballa tikoloho.

Litaelo tsa tšebeliso:

➢ Ka tloaelo, sistimi ea karabelo e tlameha ho kenyelletsa substrate (aldehydes / ketones, HCN), tharollo ea buffer (optimum reaction pH) le li-enzyme.
➢ Kaofela li-ES-HNL li ka lekoa ka ho latellana tsamaisong ea karabelo e kaholimo kapa ka HNL Screening Kit (SynKit HNL).
➢ Mefuta eohle ea li-ES-HNL tse tsamaellanang le maemo a fapaneng a karabelo a nepahetseng li lokela ho ithutoa ka bonngoe.
➢ High concentration Substrate kapa sehlahisoa se nang le sona se ka sitisa tšebetso ea ES-HNL.Leha ho le joalo, inhibition e ka imoloha ka ho eketsoa ha sehlopha sa substrate.