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Ketoreductase (KRED)
Mabapi le Ketoreductase
Li-Enzyme: Ke li-macromolecular biological catalysts, li-enzyme tse ngata ke liprotheine.
Ketoreductase: E boetse e bitsoa "Carbonyl reductase", ke li-enzyme tse susumetsang karabelo e fetohang ea redox lipakeng tsa aldehydes / ketone le joala, 'me li hloka li-coenzymes joalo ka H transmitter joalo ka NADH kapa NADPH.Ho na le lihlopha tse tharo tse kholo tsa KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), le Aldo-KetoReductases (AKRs).Mesebetsi ea matla ea boraro e tšoana, empa sebopeho le thepa li fapane haholo.
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Transaminase (ATA)
Mabapi le transaminase
ATA ho tsoa ho SyncoZymes: Ho na le mefuta e 66 ea lihlahisoa tsa enzyme tsa ATA (Palo e le ES-ATA-101~ES-ATA-166) e ntlafalitsoeng ke SyncoZymes.SZ-ATA ke sesebelisoa se molemo sa ho etsa hore regio- le stereoselective synthesis ea chiral amines, amino acid le lihlahisoa tsa tsona tse tsoang ho mefuta e sa tšoaneng ea aliphatic le monko o monate oa ketoacids, aldehydes, ketones le ketose.
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Nitrilase (NIT)
Mabapi le Nitrilase
ES-NITs: Ka ho toba fetola sehlopha sa cyanide ho sehlopha sa carboxyl, ho lokisa carboxylic acid, e sebelisoang haholo meriana, ts'ireletso ea tikoloho, indasteri ea lik'hemik'hale, tlatsetso ea lijo, masela, tlhahiso ea temo le masimo a mang.
Ho na le mefuta e 40 ea lihlahisoa tsa Nitrilase(NIT) (Palo e le ES-NIT-101~ES-NIT-140) e ntlafalitsoeng ke SyncoZymes.ES-NIT ke sesebelisoa se sebetsang sa ho etsa tlhahiso ea li-chiral carboxylic acid ka regio- le stereoelective hydrolysis ea mefuta e mengata e fapaneng ea aliphatic le monko o monate.Mofuta oa karabelo ea Catalytic:
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Nitrile hydratase (NHT)
Mabapi le ES-NHTs
ES-NHTs: sehlopha sa metalloenzyme, se khethang ho nosetsa li-nitriles ho amide ea mantlha e lumellanang.Ha li sebelisoe haholo bakeng sa tlhahiso ea li-amino acid, li-amide, li-carboxylic acid le lihlahisoa tsa tsona, empa hape le bakeng sa ho lokisa lithethefatsi tsa chiral.Ho na le mefuta e 24 ea nitrile hydratases e entsoeng ke SyncoZymes (Palo e le ES-NHT-101～ES-NHT-124).
Mofuta oa karabelo ea Catalytic:
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Amidase (AMD)
AMD ho tsoa ho SyncoZymes: Ho na le mefuta e 19 ea lihlahisoa tsa enzyme tsa AMD (Palo e le ES-AMD-101~ES-AMD-119) e ntlafalitsoeng ke SyncoZymes.SZ-AMD ke sesebelisoa se sebetsang sa ho etsa catalyze regio- le stereoselective synthesis ea chiral carboxylic acid le tse tsoang ho tsona ho tsoa ho li-amide tse fapaneng tsa aliphatic le tse nkhang hamonate.
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Ene reductase (ERED)
Mabapi le ene reductase
ES-EREDs: Ke tsa lelapa la li-enzyme tsa khale tse mosehla tse khethang ho fokotsa C = C ho α, β -unsaturated metsoako e nang le lihlopha tse amohelang elektronike.Li sebelisoa haholo thutong ea lintho tse tsoang ho amino acid, lintho tse bioactive, li-intermediate tsa meriana, linoko le li-block tsa chiral.
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Oxynitrilases (HNL)
Mabapi le li-oxynitrilases
ES-HNLs: Enzyme ea sehlopha e etsang hore enantioselectively e tlatse ho eketsoa ha HCN ho aldehydes (ketones) ho fumana R kapa S mofuta oa cyanide alcohols, e ka fetoloang habonolo mefuteng e mengata ea lithethefatsi kapa li-intermediate tsa lithethefatsi ka mokhoa oa lik'hemik'hale.
Ho na le mefuta e 29 ea lihlahisoa tsa oxynitrilase (Palo e le ES-HNL-101～ES-HNL-129) e ntlafalitsoeng ke SyncoZymes.SZ-HNL ke sesebelisoa se molemo ho regio- le stereo- selective synthesis ea (R) -cyanohydrins kapa (S) -cyanohydrins ho tsoa mefuteng e fapaneng ea monko o monate, aliphatic le heterocyclic aldehydes kapa esita le ketone.
Mofuta oa karabelo ea Catalytic:
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Nitro reductase (NTR)
Mabapi le nitro reductase
ES-NTRs: Ke li-flavoenzymes tse susumetsang phokotso e itšetlehileng ka NAD(P)H ea lihlopha tsa nitro ka metsoako ea nitroaromatic le nitroheterocyclic ho hydroxylamino le/kapa li-amino derivatives.Li sebelisoa haholo ho organic synthesis ea monko o monate oa hydroxylamine le amine e nkhang hamonate, kalafo ea hlahala, tlhahlobo ea baeloji le ho senyeha ha lintho tse silafatsang tikoloho.Ho na le mefuta e 12 ea lihlahisoa tsa Nitro reductase (NTR) (Palo e le ES-NTR-101~ES-NTR-112) e entsoeng ke SyncoZymes.
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Aldolase (DERA)
ES-DERAs: E ka thusa ka katleho tlatsetso ea stereoselective ea li-ketone tsa bafani ho li-aldehyde tsa receptor.Ho feta moo, karabelo e ka etsoa ka tharollo ea metsi ea pH e sa nke lehlakore ntle le mehato e khethehileng ea tšireletso.Ke ba sehlopha sa I aldolase, se etsang Shiff base ts'ebetsong ea ts'ebetso.Substrate e kopantsoe ka mokhoa o kopanetsoeng le sehlopha sa amino sa sebaka se sebetsang ho qala ho senya le ho thehoa ha tlamo.Phapang lipakeng tsa li-DERA le li-aldolase tse ling ke hore li-substrates tseo li li hlahisang ke aldehydes 'me li ka ba le condensation e tsoelang pele ea aldehydes.
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Cytochrome P450 monooxygenase (CYP)
Mabapi le CYP
ES-CYPs: Sehlopha sa li-enzyme tsa redox tse nang le mercaptan-heme e le setsi se sebetsang sa ho susumetsa phetisetso ea oksijene.Ke li-oksijene tsa ho qetela 'me li hloka heme ho kenya oksijene tšebetsong.
Cytochrome P450 monooxygenase e etsa hore oxidation, epoxidation le hydroxylation ea alkyl, hydroxylation le oxidation ea ammonia, oxidation ea sebabole, dealkylation (oksijene, sebabole, ammonia), oxidative dehydrogenation, deamination le dehalogenation.
Ho na le mefuta e 8 ea lihlahisoa tsa cytochrome P450 monooxygenase (Palo e le ES-CYP-101～ES-CYP-108) e ntlafalitsoeng ke SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
E-mail:lchen@syncozymes.com
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Alcohol oxidase (AOX)
Mabapi le oxidase ea joala
ES-AOXs: Li-enzyme tsena li khona ho etsa hore oxidation ea lino tse mafura kapa aryl-alcohols li etse aldehydes.Ba sebelisa oksijene ea molek'hule empa ha e hloke cofactor e kentsoeng ka ntle, le hydrogen peroxide e hlahisoa.
Ho na le mefuta e 6 ea lihlahisoa tsa alcohol oxidase (Palo e le ES-AOX-101~ES-AOX-106) e ntlafalitsoeng ke SyncoZymes.ES-AOX101 le ES-AOX102 li khetha li-aliphatic alcohol substrates, ES-AOX103~ ES-AOX105 li khetha li-aromatic alcohol substrates, 'me ES-AOX106 ke cholesterol oxidase.SZ-AOX ke sesebelisoa se sebetsang sa ho etsa hore oxidation ea lino tse mafura kapa aryl-alcohols li hlahise aldehydes.
Mofuta oa karabelo ea Catalytic:
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D-Amino acid dehydrogenase (D-AADH)
Mabapi le D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): enzyme e ka fokotsang 2-keto acid hore e be D-amino acid e lumellanang.Karabelo e hloka NADP(H) le mofani oa ammonia oa inorganic (joalo ka ammonia kapa ammonium ion).Ho na le mefuta e 17 ea D-amino acid dehydrogenases (Palo e le ES-DAADH-101~ ES-DAADH-117) e ntlafalitsoeng ke SyncoZymes.
Mofuta oa karabelo ea Catalytic:
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